Carrie goes on a date with furniture designer Aidan Shaw, but has to conceal her smoking habit. Samantha's new relationship is beset by racial politics.
Desmond wakes up and finds to his horror that Charles Widmore has taken him back to the island. He attacks Widmore, who tells him the island is not finished with him yet, and that if Desmond does not help him, all the people he cares about will die.
The ER is quarantined when a viral outbreak jeopardises the lives of the doctors and patients; a young girl whom Leanne bonded with a year ago when she lost her father returns to Angels Memorial.
The team spring into action when a Syrian is attacked while delivering evidence of a terrible chemical weapons crime.
Marty arrives at work to find spurned adversary, Greg Norbert, announcing a potential acquisition. Roscoe is confused by his feelings.