The team investigate a serial killer who is targeting women on the campus of a small Midwestern college.
After a series of suspicious murders occur, Prentiss suspects her old Interpol nemesis, making her fear for the safety of her BAU team as he closes in on her.
The janitor gives the Sacred Heart staff a lesson in being environmentally conscious; J.D.'s brother (Tom Cavanagh) returns to town and tells him to grow up.
JD and Turk try to show up Dr Cox when he can't seem to diagnose one of his patients' problems, Elliot and Carla try to convince the board not to force Dr Kelso into retirement, and Dr Kelso reflects on his time at the hospital.
Dr Cox reflects on his difficult day at work by telling his son about it as an imaginative fairy tale featuring a little village called Sacred Heartlia.