As Frank races to stop a biological weapon attack on the city, he tries to hide the threat of danger from his family; Jamie and Danny's conflict comes to a head.
Amidst Holmes and Watson's battle with tech billionaire Odin Reichenbach, the duo receives word of their old enemy and Sherlock's former love, Jamie Moriarty.
Holmes engages an old foe to protect his father, after learning Morland is in danger. Holmes and Watson search for a killer connected to the tobacco industry.
A political pollster's predictions uncharacteristically fail as he becomes the next person of interest; a direct order from Moreno sidelines Reese.
To keep tabs on a talented young officer, Reese volunteers as a police academy instructor; Martine searches for a member of the team.
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