In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.
A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient (guest star John Scurti) who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
A well known performance artist is admitted to the hospital. However, when the team learns that her symptoms may have been self-inflicted they begin to question if they are unwittingly participating in the creation of a piece of her art.
Thirteen is surprised to see House waiting for her on her release from prison, armed with plans for the two of them for the next few days. Back at the hospital, the team treats a science teacher suffering with a severe respiratory illness, and Taub tries to get back on the dating scene.
In trying times, Thirteen helps a particularly desperate friend in need. Shocking news awaits House and Taub.
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