Paramedics Josh and Sophie head to a warehouse where a forklift has rolled over. In Liverpool, paramedics face a car accident where a pregnant woman's waters have broken on impact.

The high volume of Saturday night calls contributes to severe delays at Liverpool Hospital, leading to a shortage in ambulances and long wait times for patients. Out on the streets, paramedics struggle to free patients from the wreckage of a horrific motor vehicle accident, deal with an intoxicated man with injuries, and worry about the possibility of a traumatic brain injury.

A call taker tries to revive a hanging patient over the phone when the family has already given up, and a heart attack turns into a race against the clock. A double stabbing pushes the NSW Ambulance services to their limits, while an elderly patient in late-stage emphysema shares her most intimate stories.

It's not an ordinary Sunday for NSW Ambulance as eighty thousand people hit the streets in Sydney's annual City2Surf. Paramedics drive through the crowds to locate a semi-conscious participant suffering from hyperthermia, and a seventy-year-old who collapses after completing the fourteen-kilometre run. Drugs are prominent over the weekend, with a heroin overdose resulting in a cardiac arrest on the street and an ice user crashing his vehicle.

A team of paramedics and the Ambulance helicopter medical crew rush to save a cyclist with serious head injuries, and paramedics are scrambled to deal with a spate of party drug overdoses on Sydney's Oxford Street late on Friday night. After a mentally ill patient calls triple zero 10 times in one morning, paramedics are sent to check on his welfare.

Crews are called to a motorcycle accident in peak hour traffic, and paramedics must solve the cause of an elderly woman's excruciating pain. Call taker Laura celebrates her last shift in the control centre before leaving to become a paramedic, while a devastating car crash on the far outskirts of Sydney throws crews into overdrive as they face the tyranny of distance.