Spike, a bounty hunter, and his partner Jet Black head to the Tijuana asteroid colony on their ship, the Bebop, to track down a bounty-head named Asimov Solensan, wanted for murder and the theft of a dangerous combat drug known as Bloody-Eye.

Spike and Jet are hired to recover an unusual item that has been stolen from a research laboratory. Spike is led on a wild chase, first by the thief, and then by the item itself.

Legendary gambler Faye Valentine is on the run with a six million woolong price on her head. Later, a casino-owner Gordon makes her an offer she can't refuse.

Ever since escaped convict Twinkle Maria Murdock took over, the Space Warriors ecological group have become increasingly militant.

Spike's past comes back to haunt him as he goes after a member of the Red Dragon Syndicate. For Spike to survive he will have to face his old friend and comrade, Vicious, alone.

Spike and Jet meet Wen, a musical child prodigy. But there is something strange about him. There may be a connection between this kid and the stone a man handed to Spike with his dying breath.