Snake hunter Dusty Crum wages war on thousands of invasive pythons in the Florida Everglades; he is backed by a one-of-a-kind team of snake hunters.

Rival snake hunters encroach on Dusty's hunting spot, so he and his team take a major risk by day and night hunting deep in the dangerous Sawgrass Plains.

Dusty and his team mount a hunt from a swamp buggy before racing south to the python-infested Ten Thousand Islands off the coast of southwest Florida.

Dusty leads the team to an abandoned missile factory near the epicenter of the snake epidemic that could hold the biggest concentration of pythons in the Everglades.

Dusty and the team discover a frightening new hybrid python species after trekking deep into the dense Python Pines to prevent the snakes from laying eggs.

When a potentially record-breaking python escapes Dusty's grasp, his obsession to catch it brings him face to face with the massive reptile in the most dangerous solo mission of his career.