Sho's life is changed when a mysterious man escapes with a box.

Sho uses the Guyver unit to protect his friend.

Sho faces off against Lisker and Zoanoid soldiers.

Sho must activate the Guyver unit and fend off more Zoanoids.

Genzo Makashima, ex-head of Cronos Japan and Agito Makashima's foster father, is punished by being processed as a Zoanoid.

Guyot introduces ENZYME and reveals his plan to capture Guyver I.