Rebooting the hit movie franchise of the same name, `Lethal Weapon' is set in modern-day Los Angeles, where Detective Roger Murtaugh works on various crimes. Some of Murtaugh's colleagues at the LAPD include Detective Bailey, Captain Brooks Avery and a pathologist named Scorsese. Murtaugh, married to Trish, and a father of three, finds himself working with Detective Wesley Cole, a former international CIA operative who has been everywhere and seen everything. Cole must adjust to life on the West Coast while navigating his partnership with Murtaugh.