Most Extreme Humans

Mark's hands are 20 times bigger than a normal adult male's; after learning that his condition may require amputation, Mark stopped seeing doctors; now troubling changes to his hands mean he must go back.

Winner of Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured. With 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

Most Extreme Humans follows people from around the globe living with the world's rarest and most remarkable physical conditions and examines what everyday life looks like when the world is not built with your body in mind.

Life defined by height: in Turkey, the world's tallest woman lives with an unknown genetic condition linked to extreme growth and fragile bones, while in Brazil, the world's shortest couple navigate dwarfism and its physical challenges.

Milagros lives with tumours so heavy that her face droops down to her torso.