Poong, the Joseon Psychiatrist

Yoo Se-yeop, a renowned physician, gets kicked out of Hanyang after a tragic incident. When he is about to take his own life, a mysterious woman saves him in the nick of time.

Eun-woo arrives at Gyesoo Clinic in a critical condition, which prompts Se-yeop to look into the matter. Se-yeop changes his name when he meets an old woman.

The unexpected appearance of a gumiho in Sorak sends everyone into a state of panic. Se-poong and Eun-woo begin digging for clues. A royal inspector searches for Yoo Se-yeop.

Se-poong's painful past catches up with him. A woman suffering from hand tremors visits Gyesoo Clinic for examination, which troubles Man-bok.

Se-poong and Eun-woo race against time to rescue Man-bok and strive to unravel the truth behind Gae-ban's death. Rumours about the king's mysterious death spread, prompting Jo Tae-hak to come up with an evil plot.

Se-poong and Eun-woo continue to treat patients together, and Sin-woo gets jealous of their closeness. The mystery behind the night of the King's death remains unsolved.