Yoo Se-yeop, a renowned physician, gets kicked out of Hanyang after a tragic incident. When he is about to take his own life, a mysterious woman saves him in the nick of time.
Eun-woo arrives at Gyesoo Clinic in a critical condition, which prompts Se-yeop to look into the matter; Se-yeop changes his name when he meets an old woman.
The unexpected appearance of a gumiho in Sorak sends everyone into a state of panic. Se-poong and Eun-woo begin digging for clues; a royal inspector searches for Yoo Se-yeop.
Se-poong's painful past catches up with him; a woman suffering from hand tremors visits Gyesoo Clinic for examination, which troubles Man-bok.
Se-poong and Eun-woo race against time to rescue Man-bok and strive to unravel the truth behind Gae-ban's death; rumours about the king's mysterious death spread, prompting Jo Tae-hak to come up with an evil plot.
Se-poong and Eun-woo continue to treat patients together, and Sin-woo gets jealous of their closeness; the mystery behind the night of the King's death remains unsolved.
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