After the renowned actor Arthur Leander collapses during a performance of King Lear amid news of a fast-acting, lethal flu's spread, Jeevan Chaudhary meets young, stranded actress Kirsten Raymonde, and soon both face a life-changing decision.

Twenty years after the beginning of the outbreak, Kirsten and her Shakespearean troupe, the Traveling Symphony, meet a mysterious man on their way to perform at St. Deborah-by-the-Water.

With her business trip to Malaysia up-ended by the outbreak, Miranda Carroll reflects on her past relationship with Arthur and Dr Eleven. An unexpected chance at survival sends Miranda on a dangerous journey outside the safety of her hotel.

After Kirsten nudges the Travelling Symphony off-course to help unravel the mystery of the Prophet, a much grimmer truth is revealed.

After an unexpected landing in Severn City, Arthur's ex-wife Elizabeth, son Tyler, and friend Clark confront an even more uncertain future.

While Kirsten leaves the Traveling Symphony behind to track down the Prophet, the Conductor accepts an invitation for the rest of the grieving troupe that breaks her heart.