A mysterious virus arrives in New York in the first episode of the chilling horror series created by Guillermo del Toro.

While Eph investigates the cause of the virus, one of the survivors develops a thirst for blood.

As the survivors continue to deteriorate, Redfern is quarantined. Meanwhile, Eph tries to find out what happened to Emma.

Jim makes a confession, Eldritch Palmer hires a hacker to bring down the city's communications systems and Ansel's wife is confronted with his disease.

Eph joins forces with Abraham, while exterminator Vasiliy heads to the sewers tracking rats that have been exhibiting strange behaviour.

Eph is arrested by the FBI, while the eclipse reveals the true extent of the vampire plague.