Jefferson's early life is detailed from his time at William & Mary, the building of Monticello, to his marriage and children. While he was laying the foundations of a new government, his work was interrupted by a series of personal losses.

As president, Jefferson was responsible for doubling the size of the country with the Louisiana Purchase. His battles with the Federalist movement; his relationship with his slave, Sally Hemings; and his Monticello retirement are explored.