In the late 1980s, Ace (Wood Harris) is a young man employed by a Harlem dry cleaning shop, working hard to stay out of the drug business. While making deliveries, he meets Lulu (Esai Morales), a drug dealer who convinces Ace to join him. Ace recruits his friends Mitch (Mekhi Phifer) and Rico (Cam'ron), and the trio become major players in the Harlem drug underworld, a violent business that will test the friends' loyalty and wits as the money rolls in and the dangers grow beyond their control.