故事背景是1900年，紐約市區的一所尼克醫院裡，一群醫界先驅如何在高死亡率且無抗生素的年代濟世救人。
第 1 集
Method and Madness
Series premiere. Dr. John Thackery ascends to the role of chief surgeon at The Knick, but is forced to hire a black assistant chief.
第 2 集
Mr. Paris Shoes
Thackery tasks Barrow over a dearth of cadavers. Edwards opens a covert basement clinic.
第 3 集
The Busy Flea
Thackery is asked to perform reconstructive surgrey on an old flame. Algernon has a frustrating day at work.
第 4 集
Where's The Dignity?
Algernon forces Thackery's hand in surgery, angering Gallinger. Cleary and Sister Harriet strike a deal.
第 5 集
They Capture The Heat
The Knick considers purchasing in a new invention. Barrow enlists Thackery to operate on a Collier thug.
第 6 集
Start Calling Me Dad
Thackery vows to reverse a series of failed operations. Edwards finds his clinic, and career, in jeopardy.
基夫奧雲
安德烈·荷蘭
傑瑞米·鮑勃
茱麗葉·瑞蘭斯
伊芙曉遜
麥可·安格蘭諾
卡拉·西摩爾
Eric Johnson
Chris Sullivan
Grainger Hines
David Fierro
