Dr. Burns (Joseph Ruskin) is experimenting with snake venom as a means of controlling violent tendencies in humans when things go wrong and a giant cobra escapes from his lab and into a small town. Snake-bitten bodies turn up everywhere, and the mayor of the town, Ed Biddle (Hoyt Axton), wants things hushed up to protect the town's upcoming microbrewery festival. Expert reptile wrangler Nick Hashimoto (Pat Morita) is then hired to bring in the snake before things spiral out of control.