The team investigates a murder linked to a counterfeit diamond operation, but an illness forces Jane to direct his colleagues from the office as he recuperates. Meanwhile, Abbott is concerned that transgressions in his past could harm his wife's chance to obtain a prestigious job in Washington D.C.
Charlie contacts Sam and Dean after she finds the book of the dead -- which could help eliminate the mark of Cain; Castiel and Metatron look for Castiel's grace.
Nick, Hank and Wu investigate a terrifying new Wesen who terrorizes a young family; Renard is reeling after an unexpected guest appears.
Moretti tracks down a kidnapper; Pierce and Moretti find out that there may be a child who needs their help; Donnie considers buying a house in the suburbs.