An ambulance crash endangers the lives of the paramedics involved; Bailey treats a patient who refuses her help; Ava returns for Alex and meets his other girlfriend.
Meredith furiously works to save the life of a paramedic trapped in an ambulance; Lexie holds a patient's life in her hands; Derek must rely on a nurse's help to save a patient; Bailey struggles to balance her personal life with work.
Jane works with a local astrologer who insists on helping the team with a triple homicide involving two cops and Jane's old nemesis, Red John.
Flashbacks unveil how Lincoln, Sucre, T-Bag, C-Note and Dr. Sara ended up in prison and what drove Michael to plan his brother's escape.
Michael, Lincoln and their fellow inmates run for their lives and their freedom, with Bellick in pursuit; Veronica races to Montana.
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