Romantic sparks begin to fly when Patrick Jane and supposed psychic Kristina Frye (guest star Leslie Hope) cross paths again during the CBI investigation into the murder of a charismatic head of a non-profit organization that fights human trafficking.
When a media mogul is murdered, Patrick Jane and the CBI team investigate cult leader Bret Stiles (guest star Malcolm McDowell), who may have had an axe to grind following the publication of a critical story about his group.
House reclaims his role as head of diagnostics in time to treat an adult film star admitted to the hospital for pulsating eye pain; Cuddy is reminded that Princeton Plainsboro is not conducive to healthy personal relationships.
Leslie and Ben disagree about her campaign ad; Chris makes Ron uncomfortable; Andy and April go to the doctor.
Convinced he will be sent to jail, Hal imparts fatherly advice and confesses to Malcolm about his poor work ethic.