The team discovers a disturbing family secret while trying to find a bone marrow match for an ailing teen; House tries to remove his ankle monitor so he can go to a boxing match; Taub's ex-wife wants to move across the country with their daughter.
After learning that Thirteen spent time in prison, House tries to figure out why she was incarcerated; the team makes a discovery about a teacher who has severe respiratory problems.
The team questions the necessity of the treatments it is giving a performance artist; House's unexpected action may forever change his relationships with Wilson and Cuddy.
Thirteen turns to Chase when a friend comes to her in need of medical attention and can't be taken to the hospital; House gets devastating news.
In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.