Renowned bear handler Jeff Watson says goodbye to his family and friends and sets out on an adventure into the wilderness of Southern Indiana to teach his two 700lb grizzly bears Bob and Screech how to survive on their own in the wild.

Jeff releases his bears, Bob and Screech, into the habitat where he begins his lifelong dream of re-wilding them; the first lesson, fishing, proves more difficult than Jeff imagined and Bob appears to fall behind Screech.

Jeff teaches the bears to forage in the wild, but Bob's foot continues to be a concern; when the bear slashes Jeff in the arm, he refuses medical care; after losing the bears, Jeff must think about the difficulty of them actually leaving the nest.

Jeff's unconventional hunting lessons fail to prepare Bob and Screech to hunt game in the wild, but he discovers they may be learning on their own.

Bob and Screech learn how to feed themselves, to Jeff's delight; how to den up for the winter; the grizzlies get territorial.

As the bears' re-wilding journey nears its end, Jeff has one lesson left to teach - fear of humans; their release date is imminent but they must be ready to survive on their own.