Pemeran & Kru
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Tobey MaguirePeter Parker/Spider-Man - Kirsten DunstMary Jane Watson
- James FrancoHarry Osborn/New Goblin
- Thomas Haden ChurchFlint Marko/Sandman
- Topher GraceEddie Brock/Venom
- Bryce Dallas HowardGwen Stacy
- Rosemary HarrisMay Parker
- J. K. SimmonsJ.K. Jameson
- James CromwellCaptain Stacy
- Theresa RussellEmma Marko
- Dylan BakerDr. Curt Connors
- Bill NunnJoseph 'Robbie' Robertson
- Bruce CampbellMaitre de'
- Elizabeth BanksMiss Brant
- Ted RaimiHoffman
- Perla Haney-JardinePenny Marko
- Willem DafoeNorman Osborn/Green Goblin
- Cliff RobertsonBen Parker
- Sam RaimiSutradara
- Stan LeeProduser
- Joseph M. CaraccioloProduser
- Kevin FeigeProduser
- Avi AradProduser
- Grant CurtisProduser
- Laura ZiskinProduser
- Sam RaimiPenulis
- Ivan RaimiPenulis
- Alvin SargentPenulis