Pemeran & Kru
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Tobey MaguirePeter Parker / Spider-Man - Kirsten DunstMary Jane Watson
- James FrancoHarry Osborn
- Alfred MolinaDoc Ock / Dr. Otto Octavius
- Rosemary HarrisMay Parker
- J. K. SimmonsJ. Jonah Jameson
- Donna MurphyRosie Octavius
- Peter McRobbieOsCorp Representative
- John LandisDoctor
- Joey DiazTrain Passenger
- Daniel Dae KimRaymond
- Parry ShenVoice Artist
- Sam RaimiSutradara
- Avi AradProduser
- Joseph M. CaraccioloProduser
- Laura ZiskinProduser
- Kevin FeigeProduser
- Stan LeeProduser
- Alvin SargentPenulis
- Alfred GoughPenulis
- Miles MillarPenulis
- Michael ChabonPenulis