Patrick and Laura's weekend vacation in a secluded cabin suddenly turns into a desperate fight for survival when a posse of sociopathic killers with a merciless leader (Robert Patrick), descend upon the house. Unaware that he's a trained doctor, the gang stab Patrick in the heart and leave him for dead. Knowing that if he removes the blade he will die instantly, Patrick must attempt the impossible before he bleeds to death- saving his wife from the killers with a 10-inch hunting knife lodged in his chest.