How can someone love you yesterday and not today? Shortly after her boyfriend sends his 12-year-old brother (Wilbur) to break the news that she's dumped, Frankie Browne (27) discovers that she has a loser in love gene. Every man she goes out with will inevitably break up with her. And Frankie is not alone. It is estimated by scientists that one in five people have the gene for romantic misfortune. Facing a lifetime of romantic failure, Frankie turns to the only genetics expert she knows: her former nemesis, Wilbur, a schoolboy science prodigy. Wilbur develops a maverick theory to reverse her romantic fortunes, based on his work studying the DNA of hamsters. This theory sets into motion an unexpected and comic journey into Frankie's past and her questionable romantic choices, as Frankie struggles to understand the intricacies of the human heart and whether your genes are truly your destiny.