The star of the school football team dies after taking an overdose of painkillers and Alicia is given the task of representing the doctor who prescribed the medication. Elsewhere, Peter's mother Jackie has a stroke and Alicia gives Peter news on his deadly rival Glenn Childs, which makes his blood boil.
Sherlock pursues Martin Ennis, an unpredictable criminal, before he strikes again. During the investigation, Sherlock is forced to work alongside Kathryn Drummond, the FBI profiler who literally wrote the book on Ennis.
Danny contemplates retiring until Erin enlists him to help her with a case involving her ex-husband, Jack. Jamie and Eddie go undercover as a couple, and Frank butts heads with the new mayor of New York City, Margaret Dutton.
Danny and Baez search for a veteran who may have PTSD, and a woman seeking justice for her murdered daughter catches Frank off-guard during a press conference.
When a ten-year-old boy is the victim of an incident in the projects, Danny's heated approach to the case lands him in anger management class.