The BAU team heads to Texas to track a serial killer targeting illegal immigrants attempting to make safe passage into the U.S.
As racial tensions simmer inside the prison and Veronica digs into Lincoln's case, Michael tries to get a drug that will help him test positive for diabetes, and to secure a large bolt he can use in his escape plan.
Michael obtains some caustic chemicals to use in his escape plan, while his psychotic new cellmate Haywire develops an uncomfortable fascination with his tattoos. Unaware that she is being monitored by shady Secret Service agents, Veronica enlists further legal help in her investigation.
Flashbacks shed light on the past actions that led to the incarceration of Lincoln, Sucre, T-Bag and C-Note. Also, the basis of Michael's ingenious break-out plan is revealed, and Sara recalls how she ended up working at Fox River.
Lincoln and LJ are liberated by some mysterious rescuers, Sara and Michael are finally reunited, and T-Bag tries his best to keep the location of the money a secret from Bellick and Geary.