A gas tanker explodes on a highway, resulting in multiple injuries; Jo and Meredith try to help a frantic woman, whose child has a mysterious illness; Alex is forced to work with Jo's boyfriend.
Frasier appears on a teen-oriented radio show and is interrogated by the brainy panellists, and Niles tries to show his love for Daphne in a more spontaneous way.
Jane comes face-to-face with cult leader Bret Stiles, who offers up some information regarding Red John and the missing Kristina Frye.
A South Korean ambassador is a target for assassination at a state wedding. The plot thickens when another individual is gunned down instead.
In the wake of the disastrous Meade/Slater nuptials, Wilhelmina plots her next moves and Betty tries to sort things with Daniel.