The Seattle Grace staff continue to mourn George's death; George's mother arrives but is unsure of what to do with his organs.
A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.
Meredith tries to save the life of her father, who comes to the hospital with a failed liver; Izzie empathizes with a patient riddled with tumors.
Derek and the attendings go out to celebrate when he gets the grant he needs for his clinical trial; Meredith and Alex must fend for themselves during the night shift.
Meredith feels left out when Derek breaks ground on his clinical trial; Bailey's new idea does not go over well with the chief; Callie irritates her new obstetrician (Rachel Taylor).