An 18th-century orphan named Tenma meets Libra Dohko, who recruits him into the Saintly Warriors while Tenma's friend Alone meets Pandora and learns of his destiny.

Tenma trains as a saint and meets Sasha, Alone's younger sister, who he discovers to be the reincarnation of Athena. When every living thing that Alone paints ends up dead, Pandora takes him to the cathedral.

Tenma and the other Saints look for Hades' soldiers in a village in Italy, while Tenma worries about Alone and encounters Hades.

Sasha learns the fates of Tenma and Alone, but represses her grief in order to carry out her role as Athena.

Griffon Minos, one of the strongest Spectres, begins an assault on the impenetrable Sanctuary and discovers a rose garden.

Minos resists Albafica's crimson zone attack and proceeds toward the village Albafica was protecting in order to lay waste to it.