Stephen's jaw cancer is a cause for critical concern. For surgeons Prav Praveen and Sat Parmar, there simply isn't a moment to lose. They need to urgently perform an extraordinary and radical procedure - removing and discarding Stephen's jaw.

Following a liver transport, an operation to remove a rare cancer of the soft palette, and a particularly nasty open fracture of a woman's lower leg.

If surgeons don't operate on Pratyush soon, his tumour could push him into a coma, before killing him. Mariella needs a ground-breaking procedure for a recurring bowel cancer.

Laura, 29, has an incurable brain tumour. To extend her life, she needs it removed. But the very risky surgery will have a drastic effect on her memory and may even kill her.

A risky operation on a 66-year-old's massive aortic aneurism, a complicated procedure to remove an angiosarcoma, and an operation which carries a risk of facial paralysis.

Gary has a rare tumour in his spine. Leaving it in place will probably lead to paralysis, but an operation carries a huge risk. Margaret has developed a hole in her skull.