Three cases from The First 48 that feature families enveloped in personal tragedies. In New Orleans, two cousins have a deadly fight; in Memphis, a young couple disappear; and in Dallas, a woman turns on her sister-in-law.

Three different approaches to suspect interviews; detectives sit down with friends and the suspect; the boyfriend of a missing woman is questioned with hopes of finding her alive; detectives change strategy to get their murder suspect to talk.

Three cases where things get out of control in a heated moment; a man's body is found burnt after an argument with a friend; a man with cancer gets a ride home that ends in his murder; a man visiting his son is killed in a jealous rage.

Cases where forensics were key to solving homicides; detectives rely on fingerprints to solve a father's carjacking and murder; a slain woman's family finds justice through DNA; ballistics is the key to solving a man shot during a street fight.

When there are no witnesses, homicide detectives face an uphill climb to find the truth; detectives come across a bizarre homicide at an apartment fire; solving a preacher's murder hinges on a single fingerprint.

Three cases from The First 48 that were driven by revenge and resentment.