The Sanders and the Landrys are shaken when they learn that a disease called AIDS is threatening the country's blood supply. Each family has boys with haemophilia, a genetic condition that means they depend on blood products to live.

Will fights to get those in charge of blood safety to heed the danger. The Landrys struggle to keep their family together. Dr Christos Tsoukas publishes a study on haemophiliacs.

In 1985 Will Sanders questions why the Red Cross may still be distributing tainted blood when safe, heat-treated product is available. Margaret Sanders battles the prejudice surrounding AIDS.

After seven people are infected due to a company's heat-treating process, Jim Krepke joins the fight. Will scores a victory, Ben seeks direction, and Alice and Peter try to separate from each other.

The Hemophilia Society works toward compensation for victims of tainted blood. Ryan suffers the side effects of hepatitis C treatment, Peter and Darby fall in love, and Ben starts working on a more personal book.

Justice Horace leads an inquiry into the tainted blood scandal. Ben's quest for revenge intensifies, and the people Krever intends to accuse, take him to court.