କାଷ୍ଟ୍ ଓ କ୍ରୂ
-
Tobey MaguirePeter Parker / Spider-Man - Kirsten DunstMary Jane Watson
- James FrancoHarry Osborn
- Alfred MolinaDoc Ock / Dr. Otto Octavius
- Rosemary HarrisMay Parker
- J. K. SimmonsJ. Jonah Jameson
- Donna MurphyRosie Octavius
- Peter McRobbieOsCorp Representative
- John LandisDoctor
- Joey DiazTrain Passenger
- Daniel Dae KimRaymond
- Parry ShenVoice Artist
- Sam Raimiନିର୍ଦ୍ଦେଶକ
- Avi Aradପ୍ରଯୋଜକ
- Joseph M. Caraccioloପ୍ରଯୋଜକ
- Laura Ziskinପ୍ରଯୋଜକ
- Kevin Feigeପ୍ରଯୋଜକ
- Stan Leeପ୍ରଯୋଜକ
- Alvin Sargentଲେଖକ
- Alfred Goughଲେଖକ
- Miles Millarଲେଖକ
- Michael Chabonଲେଖକ