କାଷ୍ଟ୍ ଓ କ୍ରୂ
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Tobey MaguireSpider-Man / Peter Parker - Willem DafoeGreen Goblin / Norman Osborn
- Kirsten DunstMary Jane Watson
- James FrancoHarry Osborn
- Cliff RobertsonBen Parker
- Rosemary HarrisMay Parker
- J. K. SimmonsJ. Jonah Jameson
- Joe ManganielloFlash Thompson
- Gerry BeckerMaximilian Fargas
- Bill NunnJoseph 'Robbie' Robertson
- Jack BettsHenry Balkan
- Stanley AndersonGeneral Slocum
- Ron PerkinsDr. Mendell Stromm
- Octavia SpencerCheck-In Girl
- Macy GrayHerself
- Sam Raimiନିର୍ଦ୍ଦେଶକ
- Stan Leeପ୍ରଯୋଜକ
- Avi Aradପ୍ରଯୋଜକ
- Ian Bryceପ୍ରଯୋଜକ
- Laura Ziskinପ୍ରଯୋଜକ
- David Koeppଲେଖକ
- Danny Elfmanମ୍ଯୂଜିକ୍