କାଷ୍ଟ୍ ଓ କ୍ରୂ
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Tobey MaguirePeter Parker/Spider-Man - Kirsten DunstMary Jane Watson
- James FrancoHarry Osborn/New Goblin
- Thomas Haden ChurchFlint Marko/Sandman
- Topher GraceEddie Brock/Venom
- Bryce Dallas HowardGwen Stacy
- Rosemary HarrisMay Parker
- J. K. SimmonsJ.K. Jameson
- James CromwellCaptain Stacy
- Theresa RussellEmma Marko
- Dylan BakerDr. Curt Connors
- Bill NunnJoseph 'Robbie' Robertson
- Bruce CampbellMaitre de'
- Elizabeth BanksMiss Brant
- Ted RaimiHoffman
- Perla Haney-JardinePenny Marko
- Willem DafoeNorman Osborn/Green Goblin
- Cliff RobertsonBen Parker
- Sam Raimiନିର୍ଦ୍ଦେଶକ
- Stan Leeପ୍ରଯୋଜକ
- Joseph M. Caraccioloପ୍ରଯୋଜକ
- Kevin Feigeପ୍ରଯୋଜକ
- Avi Aradପ୍ରଯୋଜକ
- Grant Curtisପ୍ରଯୋଜକ
- Laura Ziskinପ୍ରଯୋଜକ
- Sam Raimiଲେଖକ
- Ivan Raimiଲେଖକ
- Alvin Sargentଲେଖକ