When a devastating infection spreads across the entire world, causing chaos and collapsing civilisation as we know it, the only safe place is in the air. A cabin crew escapes on a damaged 747 bound for Greenland but not all the passengers are as healthy as they seem... When the plane is sabotaged, the rag tag group of survivors are forced to land in an England tearing itself apart and ravaged by disease. The crew are faced with impossible life or death decisions which force them to confront their past, face their fears and fight for their very survival.