After moving into an apartment, Blythe Baxter gains the ability to communicate with animals after falling in a dumbwaiter. There, she meets a group of pets who reside in a day camp area of a pet shop, who enlist her help when the store is on the verge of running out of business.

Blythe hosts an animal fashion show featuring the pets in order to drive revenue to the pet shop. Meanwhile, the Biskit twins Brittany and Whittany plan to stop Blythe by embarrassing her during the climax of her show.

Blythe stumbles to fix a botched haircut on Zoe, while the other pets urge Minka to purse the life of an art superstar, and get out of hand when they overestimate her artistic endurance.

Blythe uses the pets as diversions in order to rescue Zoe's sister from inside Largest Ever Pet Shop, an expansive pet store retail chain owned by the Biskit twins' father, Fisher Biskit.

Blythe earns the gratitude of the Biskit twins after defending them against a bully during gym, but ends up forgetting about her other friends. Meanwhile, Pepper is inspired to use insult comedy as part of her stand-up comedy schtick, but takes it too far on Penny while being unaware of her sensitive feelings.

Penny Ling has a hard time speaking up when she disapproves of the outfit Blythe is designing for her to wear to a charity ball, while Blythe is distracted by the belief that her dad is taking a date to the same event.