Kate Jackson, Farrah Fawcett and Jaclyn Smith star as Jill, Sabrina and Kelly, beautiful ex-policewomen, who are hired as private investigators by a mysterious person known as Charlie. Charlie sends his trio of "angels" on tough assignments which may require the "feminine touch." All arrangements are made by phone, or through Woodville (Stiers), the only person who knows Charlie's identity. The other male on the private-eye team is Bosley. The scene of the current project is a huge vineyard estate in California. Charlie's client wants to prove that the missing owner, Vince Lemaire, was murdered by his wife, Rachel (Muldaur), and foreman, Beau Creel (Hopkins). The team sets up a sophisticated caper in which Jill, Sabrina and Kelly assume character roles from kidnapper and wealthy heiress to dowdy secretary. Woodville and Bosley join the caper in various business roles. Their complex and dangerous scheme convinces Creel that there is oil in a swamp on of the estate where Lemaire's body is believed to be buried. Events take a disastrous turn in the suspenseful conclusion as the girls observe and his men drag the body from the water at midnight. The trio is suddenly discovered, and must flee for their lives through the unfamiliar swamp, with no help in sight.

Sabrina becomes a racing driver, while Kelly, Jill and Bosley assume unusual disguises to ascertain why a pretty woman driver lost control of her car and died in a flaming wreck. The conspiracy they unearth extends far beyond the track.

An unwitting pilot whose plane has been used to smuggle drugs hires the Angels to crack a heroin ring operating out of Mexico.

The Angels infiltrate the world of high fashion to investigate the deaths of several models who were strangled with rag dolls.

The Angels trace a missing woman to a prison where inmates are forced into prostitution.

The Angels deduce that Charlie is the real target after several attempts on their lives all fail to succeed.