Josh Gates' search begins at a supposed portal to the underworld. Next, Josh seeks out a doctor who is conducting research to learn if consciousness survives death.

Josh talks to Deepak Chopra, who theorises that there is no true death, and that consciousness is recycled. Next, Josh travels to the holy city of Varanasi, India.

Josh talks to Penn Jillette about atheism, before travelling to Moscow to learn about transhumanism: the belief that humans will advance beyond the natural body.

In the rainforests of Peru, Josh ingests ayahuasca, a powerful hallucinogenic that shamans have used for hundreds of years to travel beyond the physical world.