Meredith grows increasingly dissatisfied with the unknown details of Derek's life. Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recovery; Izzie contemplates reconnecting with her estranged mother; Zoey, a pregnant woman in her 40s who's been diagnosed with cancer, disagrees with Cristina's medical advice; and the interns are mystified by Cable, a patient who's being treated for seizures and who thinks he's psychic.
The Wisteria Lane Neighbourhood Association leaps into action when they see the contemporary water sculpture that Bob and Lee have installed in their front garden. Elsewhere, Edie finds out about the affair that Carlos is having with Gaby, just as John Rowland - Carlos and Gaby's former gardener - turns up unexpectedly wanting to rekindle an old romance.
Edie is shocked when she receives some news at the gynaecologist's office and an unexpected visitor discovers Bree's pregnancy is a hoax.
As the women look back on Edie's life, Susan recalls their first meeting, Lynette reflects on a memorable night out, and Bree is reminded of the thoughtfulness she bestowed upon Orson.
Halloween is a night of horrors for Edie, whose worst nightmares become reality when Carlos walks out of their relationship. Elsewhere, Susan finds Mike's father, even though he was supposed to be dead, and Danielle goes into labour right in the middle of the Halloween party, but who will deliver the baby?
