Izzie and George attend to Denny as the pressure increases to find him a new heart, Cristina suddenly finds herself in charge of an ER, and Derek grapples with the realization that the life of a friend is in his hands. In the second hour, "Losing My Religion," Richard goes into interrogation mode about a patient’s condition, Callie confronts George about his feelings for her, and Meredith and Derek meet about Doc.
Recent events strain Burke and Cristina's relationship, Meredith's half-sister, Molly, is admitted to the hospital, and Mark and Derek must work together when two close-knit brothers seek medical help.
A traumatic car accident fills the ER, Cristina has a crisis of conscience about her deceptive teamwork with Burke, and Izzie pushes the boundaries of her probation.
Some very deep secrets are made painfully public when Meredith's mother, who suffers from Alzheimer's disease, is brought to Seattle Grace for a surgical procedure. Meanwhile, some frightening news about Cristina's health is brought out into the open.
A documentary crew visits the hospital six months after the shooting to document the road to recovery for doctors and patients; Meredith helps Cristina put on a brave face for the cameras.
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