Ben and Stephanie make career-changing decisions. Meanwhile, Alex and Eliza come to blows over the treatment of a young patient.
Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan.
Bailey must make a tough decision when an attending refuses to work with Eliza. Maggie's mother pays her a surprise visit and Stephanie gets pulled into Owen and Amelia's drama.
Alex returns to the hospital and discovers a lot has changed since he left. Meanwhile, Jo has to make a difficult decision on a case.
When a young boy goes missing from his home in St Louis, the BAU reinvestigates a similar cold case to search for the unsub.