After a neighbour is stabbed, Dr Choi enlists the help of April to figure out the real cause of the incident. Meanwhile, Noah misdiagnoses a patient, and Dr Reese's estranged father comes to Dr Charles, as a patient, without her knowledge.
Dr Manning and Dr Choi must deliver a baby under dire circumstances, and Dr Rhodes and Dr Bekker argue about treating a boy with a chronic disease. As Dr Halstead and April deal with an uncomfortable situation, Goodwin and Maggie deal with a lawsuit.
Dr Charles and Dr Reese search for answers when a mother brings in her daughter claiming she is possessed. Dr Rhodes and Dr Bekker are tasked with finding a way to save a pair of conjoined twins.
After taking the lead on a surgery, Dr Bekker feels the heat after something goes wrong. Dr Manning and Dr Charles are faced with a tough decision concerning a nine year old girl, and April and Dr Reese rush to find the son of a dying patient.
Dr Halstead and Dr Manning are at odds over the care of a vegetative man. Dr Rhodes goes behind Dr Bekker's back to get his patient at the top of the transplant list. A woman in the waiting room falls asleep and won't wake up.
