S6, E1: In the sixth and final season five premiere, Brainiac lays close to death after trying to stop Lex (recurring guest star JON CRYER), causing Supergirl and the team to soar in to save him, engaging in an epic battle with Gamenmae (guest star CARA BUONO). After beating Leviathan, Supergirl turns her attention to Lex, who has used the Obsidian platform to brainwash half the world to love him and follow him at all costs, no matter what horrible things he does. Knowing how dangerous this makes her brother, Lena enlists the entire team – Alex, J’onn, Dreamer, Kelly and Brainiac – to help, but Supergirl realizes that the only way to truly stop Lex is to sacrifice herself.