Infinitely Polar Bear tells the heart-warming story of Cameron (Mark Ruffalo), a man who suffers from bipolar disorder. After a breakdown forces him to leave his family, he attempts to rebuild a relationship with his two spirited daughters and win back the trust of his wife Maggie (Zoe Saldana). When Maggie decides to go away to business school, they agree that he will take care of the girls, which leads to some funny and often challenging moments as Cam attempts to prove to his family that he can be the man they need him to be.