In the 4th century A.D., astronomer and philosopher Hypatia (Rachel Weisz) teaches her scientific beliefs to a class of male students. Among them is lovestruck slave Davus (Max Minghella), the equally smitten Orestes (Oscar Isaac) and young Christian man Synesius (Rupert Evans). Hypatia dismisses all of their advances, but this romantic drama pales in comparison to a rising battle between Christians and pagans on the streets of soon-to-be war-torn Alexandria.