New Yorkers "Rusty" Panello (Harpo Marx) and his brother, Joe (Chico Marx), cheat S. Quentin Quale (Groucho Marx) out of some money, enough to buy themselves a train trip out West. All three soon find themselves involved in a feud between the Turner and Wilson clans, and two crooked land promoters. In order to help two lovers marry, Quale and the Panello brothers pursue the crooks on an eastbound train in a madcap race for justice.