In the 28th century, four rival corporations are in a constant state of war for control of the Earth. During one such battle, an ancient machine is uncovered and reactivated, and starts churning out undead mutants by the hundreds. While the corporations make plans to abandon the Earth, a strike force led by Maj. Mitch Hunter (Thomas Jane) and clergyman Brother Samuel (Ron Perlman), embark on a mission to destroy the machine before the mutants overrun the planet.